Tesamorelin — Research Evidence & Community Data
Also known as: Egrifta, GHRH analog
Research & educational use only. This content is not medical advice. Consult a qualified healthcare professional before using any peptide compound.
What Is Tesamorelin?
Tesamorelin is a synthetic growth hormone-releasing hormone (GHRH) analog approved by the FDA (as Egrifta) to reduce excess visceral abdominal fat in people with HIV-associated lipodystrophy. It is supported by phase 3 randomized controlled trials for that specific indication. It is a prescription medication and is not approved for general body-composition or anti-aging use.
Is Tesamorelin FDA Approved?
Tesamorelin is FDA approved.
What Does the Research Show?
As of 2026, there are 6 human randomized controlled trials with a combined 800 subjects, and 15 animal model studies. Phase 3 randomized controlled trials demonstrate reduced visceral adipose tissue in HIV-associated lipodystrophy. Approval is limited to that indication.
| Study | Type | Subjects | Outcome | Source |
|---|---|---|---|---|
| Tesamorelin, a growth hormone-releasing factor analogue, in HIV patients with abdominal fat accumulationFalutz J, et al. · New England Journal of Medicine · 2007 | RCT | 412 | Significant reduction in visceral adipose tissue versus placebo | DOI |
What Do Community Logs Show?
No community logs include Tesamorelin yet. Browse community logs →
How Is Tesamorelin Used in Research?
Mechanism of action. Agonism of the GHRH receptor, increasing endogenous GH and IGF-1 and reducing visceral fat.
Half-life. Approximately 25-40 minutes.
Storage. Approved product: refrigerate and follow label. Research handling differs and is unverified.
Reconstitution. Approved products are pre-formulated. Reconstitution math applies only to lyophilized material - not medical advice. See the reconstitution calculator — a math tool only, not dosing guidance.
What Does Tesamorelin's Evidence Tier Mean?
Tesamorelin is rated Tier 1 · RCT Evidence. Supported by human randomized controlled trials. Evidence tiers are a shorthand for how strong the human data is — Tier 1 reflects human randomized controlled trials, while lower tiers rest on observational, animal, or theoretical evidence. A higher tier means more confidence that observed effects are real and caused by the compound rather than by chance or bias. For how to weigh each tier, see our guide to understanding peptide evidence tiers.
How Do You Evaluate Tesamorelin Sourcing and Quality?
Because research-chemical Tesamorelin is unregulated, sourcing quality varies widely between sellers. Before trusting any supplier, check its reputation and enforcement history in the ranked list of trusted peptide sellers, and look for a batch-specific certificate of analysis (COA) showing third-party HPLC or LC-MS purity testing. Purity claims without a named lab, a batch number, and a method are marketing, not data. If you are reconstituting lyophilized material, the reconstitution calculator handles the arithmetic — it is a math tool only and not dosing guidance.
Where to Buy Tesamorelin: Trusted & Verified Sellers
Tesamorelin is supplied by specialist research-chemical sellers rather than pharmacies, so where you buy it matters as much as what you buy. The sellers below have published moderator-approved third-party lab results for Tesamorelin, ranked by overall reputation score. Always confirm a current batch-specific COA before purchasing.
No seller has published a lab result for Tesamorelin yet. Browse the ranked directory of trusted peptide sellers and check each one's lab testing and enforcement record before buying.
PeptidesHub does not sell Tesamorelin or facilitate transactions — this list is for research transparency only.
How Are Adverse Reactions to Tesamorelin Reported?
Structured adverse-event reports help the whole community spot safety signals early. You can browse approved reports on the adverse events page or submit one yourself. For a serious or life-threatening reaction, seek medical care and report it to FDA MedWatch.
Frequently Asked Questions
Tesamorelin is FDA approved.