Ipamorelin — Research Evidence & Community Data
Also known as: GH secretagogue, pentapeptide secretagogue
Research & educational use only. This content is not medical advice. Consult a qualified healthcare professional before using any peptide compound.
What Is Ipamorelin?
Ipamorelin is a synthetic pentapeptide and selective growth hormone secretagogue that mimics ghrelin at the GHS-R1a receptor to stimulate pulsatile growth hormone release. It is not FDA-approved and has not been evaluated in published human efficacy randomized controlled trials; the evidence base is preclinical. It is studied for relatively selective GH release with minimal effect on cortisol or prolactin.
Is Ipamorelin FDA Approved?
Ipamorelin is not fda approved. It is treated as a research compound in the United States with no approved human clinical applications.
What Does the Research Show?
As of 2026, there are 0 human randomized controlled trials with a combined 0 subjects, and 20 animal model studies. Preclinical pharmacology and animal data describe selective GH release. No published human efficacy RCTs.
No linked evidence entries yet.
What Do Community Logs Show?
1 community protocol logs include Ipamorelin. Browse community logs →
How Is Ipamorelin Used in Research?
Mechanism of action. Selective agonism of the ghrelin / growth-hormone secretagogue receptor (GHS-R1a), stimulating pituitary GH release without strongly raising cortisol or prolactin.
Half-life. Reported plasma half-life around 2 hours in animal models.
Storage. Lyophilized: store frozen, protect from light. Reconstituted: refrigerate 2-8C.
Reconstitution. Reconstituted with bacteriostatic water for research handling. Math only - not dosing guidance. See the reconstitution calculator — a math tool only, not dosing guidance.
What Does Ipamorelin's Evidence Tier Mean?
Ipamorelin is rated Tier 3 · Animal Only. Evidence limited to animal models. Evidence tiers are a shorthand for how strong the human data is — Tier 1 reflects human randomized controlled trials, while lower tiers rest on observational, animal, or theoretical evidence. A higher tier means more confidence that observed effects are real and caused by the compound rather than by chance or bias. For how to weigh each tier, see our guide to understanding peptide evidence tiers.
How Do You Evaluate Ipamorelin Sourcing and Quality?
Because research-chemical Ipamorelin is unregulated, sourcing quality varies widely between sellers. Before trusting any supplier, check its reputation and enforcement history in the ranked list of trusted peptide sellers, and look for a batch-specific certificate of analysis (COA) showing third-party HPLC or LC-MS purity testing. Purity claims without a named lab, a batch number, and a method are marketing, not data. If you are reconstituting lyophilized material, the reconstitution calculator handles the arithmetic — it is a math tool only and not dosing guidance.
Where to Buy Ipamorelin: Trusted & Verified Sellers
Ipamorelin is supplied by specialist research-chemical sellers rather than pharmacies, so where you buy it matters as much as what you buy. The sellers below have published moderator-approved third-party lab results for Ipamorelin, ranked by overall reputation score. Always confirm a current batch-specific COA before purchasing.
PeptidesHub does not sell Ipamorelin or facilitate transactions — this list is for research transparency only.
How Are Adverse Reactions to Ipamorelin Reported?
Structured adverse-event reports help the whole community spot safety signals early. You can browse approved reports on the adverse events page or submit one yourself. For a serious or life-threatening reaction, seek medical care and report it to FDA MedWatch.
Frequently Asked Questions
Ipamorelin is not fda approved. It is treated as a research compound in the United States.