Sermorelin — Research Evidence & Community Data
Also known as: GHRH 1-29, Geref
Research & educational use only. This content is not medical advice. Consult a qualified healthcare professional before using any peptide compound.
What Is Sermorelin?
Sermorelin is a synthetic peptide corresponding to the first 29 amino acids of growth hormone-releasing hormone (GHRH 1-29). It was previously marketed in the United States (as Geref) for diagnostic and pediatric growth indications and is no longer sold as an approved product, though it remains available through compounding. Human data exist mainly from its diagnostic and earlier clinical use.
Is Sermorelin FDA Approved?
Sermorelin is not fda approved. It is treated as a research compound in the United States with no approved human clinical applications.
What Does the Research Show?
As of 2026, there are 2 human randomized controlled trials with a combined 150 subjects, and 20 animal model studies. Historical clinical and diagnostic human use plus animal data. Not currently an approved marketed product in the US.
No linked evidence entries yet.
What Do Community Logs Show?
No community logs include Sermorelin yet. Browse community logs →
How Is Sermorelin Used in Research?
Mechanism of action. Agonism of the GHRH receptor, stimulating endogenous pituitary growth hormone secretion.
Half-life. Short plasma half-life (minutes).
Storage. Lyophilized: store frozen. Reconstituted: refrigerate 2-8C.
Reconstitution. Reconstituted with bacteriostatic water. Math only - not dosing guidance. See the reconstitution calculator — a math tool only, not dosing guidance.
What Does Sermorelin's Evidence Tier Mean?
Sermorelin is rated Tier 2 · Observational. Supported by human observational or clinical reports. Evidence tiers are a shorthand for how strong the human data is — Tier 1 reflects human randomized controlled trials, while lower tiers rest on observational, animal, or theoretical evidence. A higher tier means more confidence that observed effects are real and caused by the compound rather than by chance or bias. For how to weigh each tier, see our guide to understanding peptide evidence tiers.
How Do You Evaluate Sermorelin Sourcing and Quality?
Because research-chemical Sermorelin is unregulated, sourcing quality varies widely between sellers. Before trusting any supplier, check its reputation and enforcement history in the ranked list of trusted peptide sellers, and look for a batch-specific certificate of analysis (COA) showing third-party HPLC or LC-MS purity testing. Purity claims without a named lab, a batch number, and a method are marketing, not data. If you are reconstituting lyophilized material, the reconstitution calculator handles the arithmetic — it is a math tool only and not dosing guidance.
Where to Buy Sermorelin: Trusted & Verified Sellers
Sermorelin is supplied by specialist research-chemical sellers rather than pharmacies, so where you buy it matters as much as what you buy. The sellers below have published moderator-approved third-party lab results for Sermorelin, ranked by overall reputation score. Always confirm a current batch-specific COA before purchasing.
No seller has published a lab result for Sermorelin yet. Browse the ranked directory of trusted peptide sellers and check each one's lab testing and enforcement record before buying.
PeptidesHub does not sell Sermorelin or facilitate transactions — this list is for research transparency only.
How Are Adverse Reactions to Sermorelin Reported?
Structured adverse-event reports help the whole community spot safety signals early. You can browse approved reports on the adverse events page or submit one yourself. For a serious or life-threatening reaction, seek medical care and report it to FDA MedWatch.
Frequently Asked Questions
Sermorelin is not fda approved. It is treated as a research compound in the United States.