PT-141 — Research Evidence & Community Data
Also known as: Bremelanotide, Vyleesi
Research & educational use only. This content is not medical advice. Consult a qualified healthcare professional before using any peptide compound.
What Is PT-141?
Bremelanotide (PT-141) is a melanocortin receptor agonist approved by the FDA (as Vyleesi) for hypoactive sexual desire disorder (HSDD) in premenopausal women. It is supported by phase 3 randomized controlled trials (the RECONNECT program). It is an approved prescription medication administered by subcutaneous injection.
Is PT-141 FDA Approved?
PT-141 is FDA approved.
What Does the Research Show?
As of 2026, there are 3 human randomized controlled trials with a combined 1,200 subjects, and 15 animal model studies. Phase 3 randomized controlled trials support a modest but significant improvement in sexual desire in premenopausal women with HSDD.
| Study | Type | Subjects | Outcome | Source |
|---|---|---|---|---|
| Bremelanotide for hypoactive sexual desire disorder: two randomized phase 3 trials (RECONNECT)Kingsberg SA, et al. · Obstetrics & Gynecology · 2019 | RCT | 1247 | Modest significant improvement in sexual desire | — |
What Do Community Logs Show?
No community logs include PT-141 yet. Browse community logs →
How Is PT-141 Used in Research?
Mechanism of action. Agonism of central melanocortin receptors (notably MC4R), modulating neural pathways involved in sexual desire.
Half-life. Reported terminal half-life around 2-3 hours.
Storage. Approved product: follow label storage.
Reconstitution. Approved products are pre-formulated. Reconstitution math applies only to lyophilized material - not medical advice. See the reconstitution calculator — a math tool only, not dosing guidance.
What Does PT-141's Evidence Tier Mean?
PT-141 is rated Tier 1 · RCT Evidence. Supported by human randomized controlled trials. Evidence tiers are a shorthand for how strong the human data is — Tier 1 reflects human randomized controlled trials, while lower tiers rest on observational, animal, or theoretical evidence. A higher tier means more confidence that observed effects are real and caused by the compound rather than by chance or bias. For how to weigh each tier, see our guide to understanding peptide evidence tiers.
How Do You Evaluate PT-141 Sourcing and Quality?
Because research-chemical PT-141 is unregulated, sourcing quality varies widely between sellers. Before trusting any supplier, check its reputation and enforcement history in the ranked list of trusted peptide sellers, and look for a batch-specific certificate of analysis (COA) showing third-party HPLC or LC-MS purity testing. Purity claims without a named lab, a batch number, and a method are marketing, not data. If you are reconstituting lyophilized material, the reconstitution calculator handles the arithmetic — it is a math tool only and not dosing guidance.
Where to Buy PT-141: Trusted & Verified Sellers
PT-141 is supplied by specialist research-chemical sellers rather than pharmacies, so where you buy it matters as much as what you buy. The sellers below have published moderator-approved third-party lab results for PT-141, ranked by overall reputation score. Always confirm a current batch-specific COA before purchasing.
PeptidesHub does not sell PT-141 or facilitate transactions — this list is for research transparency only.
How Are Adverse Reactions to PT-141 Reported?
Structured adverse-event reports help the whole community spot safety signals early. You can browse approved reports on the adverse events page or submit one yourself. For a serious or life-threatening reaction, seek medical care and report it to FDA MedWatch.
Frequently Asked Questions
PT-141 is FDA approved.