MOTS-c — Research Evidence & Community Data
Also known as: mitochondrial-derived peptide, MOTSc
Research & educational use only. This content is not medical advice. Consult a qualified healthcare professional before using any peptide compound.
What Is MOTS-c?
MOTS-c is a mitochondrial-derived peptide encoded within the mitochondrial 12S rRNA region that acts as a regulator of metabolic homeostasis and insulin sensitivity. It is not FDA-approved and has not been studied in published human efficacy randomized controlled trials; current evidence is preclinical, with rodent studies linking it to improved metabolic and exercise-related outcomes.
Is MOTS-c FDA Approved?
MOTS-c is not fda approved. It is treated as a research compound in the United States with no approved human clinical applications.
What Does the Research Show?
As of 2026, there are 0 human randomized controlled trials with a combined 0 subjects, and 25 animal model studies. Rodent studies link MOTS-c to improved insulin sensitivity and exercise capacity. No published human efficacy RCTs.
No linked evidence entries yet.
What Do Community Logs Show?
No community logs include MOTS-c yet. Browse community logs →
How Is MOTS-c Used in Research?
Mechanism of action. Modulation of the AMPK pathway and folate-methionine metabolism, influencing insulin sensitivity and metabolic stress responses.
Half-life. Short plasma half-life reported in animal models.
Storage. Lyophilized: store frozen. Reconstituted: refrigerate 2-8C.
Reconstitution. Reconstituted with bacteriostatic water for research handling. Math only - not dosing guidance. See the reconstitution calculator — a math tool only, not dosing guidance.
What Does MOTS-c's Evidence Tier Mean?
MOTS-c is rated Tier 3 · Animal Only. Evidence limited to animal models. Evidence tiers are a shorthand for how strong the human data is — Tier 1 reflects human randomized controlled trials, while lower tiers rest on observational, animal, or theoretical evidence. A higher tier means more confidence that observed effects are real and caused by the compound rather than by chance or bias. For how to weigh each tier, see our guide to understanding peptide evidence tiers.
How Do You Evaluate MOTS-c Sourcing and Quality?
Because research-chemical MOTS-c is unregulated, sourcing quality varies widely between sellers. Before trusting any supplier, check its reputation and enforcement history in the ranked list of trusted peptide sellers, and look for a batch-specific certificate of analysis (COA) showing third-party HPLC or LC-MS purity testing. Purity claims without a named lab, a batch number, and a method are marketing, not data. If you are reconstituting lyophilized material, the reconstitution calculator handles the arithmetic — it is a math tool only and not dosing guidance.
Where to Buy MOTS-c: Trusted & Verified Sellers
MOTS-c is supplied by specialist research-chemical sellers rather than pharmacies, so where you buy it matters as much as what you buy. The sellers below have published moderator-approved third-party lab results for MOTS-c, ranked by overall reputation score. Always confirm a current batch-specific COA before purchasing.
No seller has published a lab result for MOTS-c yet. Browse the ranked directory of trusted peptide sellers and check each one's lab testing and enforcement record before buying.
PeptidesHub does not sell MOTS-c or facilitate transactions — this list is for research transparency only.
How Are Adverse Reactions to MOTS-c Reported?
Structured adverse-event reports help the whole community spot safety signals early. You can browse approved reports on the adverse events page or submit one yourself. For a serious or life-threatening reaction, seek medical care and report it to FDA MedWatch.
Frequently Asked Questions
MOTS-c is not fda approved. It is treated as a research compound in the United States.