LL-37 — Research Evidence & Community Data
Also known as: cathelicidin, human cationic antimicrobial peptide
Research & educational use only. This content is not medical advice. Consult a qualified healthcare professional before using any peptide compound.
What Is LL-37?
LL-37 is the only human cathelicidin antimicrobial peptide, with roles in innate immunity, antimicrobial defense, and wound healing. It is not FDA-approved as a therapeutic and has no established human efficacy randomized controlled trials; evidence is preclinical and mechanistic. It has context-dependent effects and has been implicated in both protective immunity and certain inflammatory conditions.
Is LL-37 FDA Approved?
LL-37 is not fda approved. It is treated as a research compound in the United States with no approved human clinical applications.
What Does the Research Show?
As of 2026, there are 0 human randomized controlled trials with a combined 0 subjects, and 20 animal model studies. Extensive mechanistic and animal data on antimicrobial and wound-healing roles, with context-dependent inflammatory effects. No established human efficacy RCTs.
No linked evidence entries yet.
What Do Community Logs Show?
No community logs include LL-37 yet. Browse community logs →
How Is LL-37 Used in Research?
Mechanism of action. Membrane-disrupting antimicrobial activity plus immunomodulatory and pro-angiogenic signaling in host defense.
Half-life. Short half-life; subject to proteolytic degradation.
Storage. Lyophilized: store frozen. Reconstituted: refrigerate 2-8C.
Reconstitution. Reconstituted per research protocol. Math only - not dosing guidance. See the reconstitution calculator — a math tool only, not dosing guidance.
What Does LL-37's Evidence Tier Mean?
LL-37 is rated Tier 3 · Animal Only. Evidence limited to animal models. Evidence tiers are a shorthand for how strong the human data is — Tier 1 reflects human randomized controlled trials, while lower tiers rest on observational, animal, or theoretical evidence. A higher tier means more confidence that observed effects are real and caused by the compound rather than by chance or bias. For how to weigh each tier, see our guide to understanding peptide evidence tiers.
How Do You Evaluate LL-37 Sourcing and Quality?
Because research-chemical LL-37 is unregulated, sourcing quality varies widely between sellers. Before trusting any supplier, check its reputation and enforcement history in the ranked list of trusted peptide sellers, and look for a batch-specific certificate of analysis (COA) showing third-party HPLC or LC-MS purity testing. Purity claims without a named lab, a batch number, and a method are marketing, not data. If you are reconstituting lyophilized material, the reconstitution calculator handles the arithmetic — it is a math tool only and not dosing guidance.
Where to Buy LL-37: Trusted & Verified Sellers
LL-37 is supplied by specialist research-chemical sellers rather than pharmacies, so where you buy it matters as much as what you buy. The sellers below have published moderator-approved third-party lab results for LL-37, ranked by overall reputation score. Always confirm a current batch-specific COA before purchasing.
No seller has published a lab result for LL-37 yet. Browse the ranked directory of trusted peptide sellers and check each one's lab testing and enforcement record before buying.
PeptidesHub does not sell LL-37 or facilitate transactions — this list is for research transparency only.
How Are Adverse Reactions to LL-37 Reported?
Structured adverse-event reports help the whole community spot safety signals early. You can browse approved reports on the adverse events page or submit one yourself. For a serious or life-threatening reaction, seek medical care and report it to FDA MedWatch.
Frequently Asked Questions
LL-37 is not fda approved. It is treated as a research compound in the United States.