AOD-9604 vs MOTS-c
Research & educational use only. This content is not medical advice. Consult a qualified healthcare professional before using any peptide compound.
AOD-9604 and MOTS-c are both metabolic peptides that come up together constantly. This is a side-by-side comparison on the data that actually matters — evidence tier, FDA status, human trials, and how to source each safely — not hype. It is for research and educational purposes only.
AOD-9604 vs MOTS-c: side-by-side
| AOD-9604 | MOTS-c | |
|---|---|---|
| Evidence tier | Tier 2 | Tier 3 |
| FDA status | Not FDA Approved | Not FDA Approved |
| Human RCTs | 3 | 0 |
| Subjects enrolled | 800 | 0 |
| Animal studies | 15 | 25 |
| Category | metabolic | metabolic |
| Half-life | Short plasma half-life. | Short plasma half-life reported in animal models. |
| Community logs | 0 | 0 |
Key differences
AOD-9604 rests on stronger human evidence (Tier 2) than MOTS-c (Tier 3) — that means more confidence its observed effects are real rather than artefacts of weaker study designs. Neither is FDA approved for human use — both are not fda approved / not fda approved and treated as research compounds in the US.
AOD-9604 has 3 human trials on record (800 subjects) versus MOTS-c's 0 (0 subjects). Evidence tiers are a shorthand for how strong that human data is — see our guide to understanding peptide evidence tiers for how to weigh them.
What is AOD-9604?
AOD-9604 is a synthetic fragment of human growth hormone (the C-terminal 176-191 region) originally developed as an anti-obesity agent. Clinical trials for weight loss did not demonstrate significant efficacy versus placebo, and it was not approved as a drug; it has since been marketed in some regions as a food or… Full AOD-9604 breakdown →
What is MOTS-c?
MOTS-c is a mitochondrial-derived peptide encoded within the mitochondrial 12S rRNA region that acts as a regulator of metabolic homeostasis and insulin sensitivity. It is not FDA-approved and has not been studied in published human efficacy randomized controlled trials; current evidence is preclinical, with rodent… Full MOTS-c breakdown →
Where to buy AOD-9604 or MOTS-c safely
Both are sold by research-chemical suppliers, not pharmacies, so the source matters as much as the compound. Before buying either, vet sellers on third-party lab testing and enforcement history in the ranked directory of trusted peptide sellers — or jump straight to vetted sources for AOD-9604 or MOTS-c. PeptidesHub does not sell either compound.
Frequently asked questions
AOD-9604 and MOTS-c are both metabolic peptides. AOD-9604 rests on stronger human evidence (Tier 2) than MOTS-c (Tier 3) — that means more confidence its observed effects are real rather than artefacts of weaker study designs. Neither is FDA approved for human use — both are not fda approved / not fda approved and treated as research compounds in the US. See each compound's full evidence breakdown for the underlying studies.