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7
The tiers are about where the evidence comes from, not a verdict on whether something "works":
- Tier 1 — human randomized controlled trials
- Tier 2 — human observational/clinical reports
- Tier 3 — animal models only
- Tier 4 — theoretical / mechanism only
BPC-157 is mostly animal data, so it lands at Tier 3. That doesn't mean it does nothing — it means the strong human proof isn't there yet. Full breakdown here.
Accepted solution
2
This reframed everything for me. "Tier 3 = promising but unproven in humans" is basically how I read it now.