TB-500 — Research Evidence & Community Data
Also known as: Thymosin Beta-4 fragment, TB4 fragment, Tβ4
Research & educational use only. This content is not medical advice. Consult a qualified healthcare professional before using any peptide compound.
What Is TB-500?
TB-500 is a synthetic peptide corresponding to the active region of Thymosin Beta-4, a naturally occurring protein involved in actin regulation and cell migration. Animal studies investigate roles in wound healing and tissue repair. It is not FDA-approved and lacks published human randomized controlled trials. It is used in research contexts to study recovery and angiogenesis.
Is TB-500 FDA Approved?
TB-500 is not fda approved. It is treated as a research compound in the United States with no approved human clinical applications.
What Does the Research Show?
As of 2026, there are 0 human randomized controlled trials with a combined 0 subjects, and 40 animal model studies. Animal data on dermal wound healing, corneal repair, and cardiac models. Full-length Thymosin Beta-4 (not TB-500) has entered early human trials for separate indications.
TB-500 itself has no completed human efficacy RCTs.
| Study | Type | Subjects | Outcome | Source |
|---|---|---|---|---|
| Thymosin beta-4 and tissue regenerationGoldstein AL, et al. · Annals of the NY Academy of Sciences · 2012 | Review | — | Reviews actin regulation and repair roles | DOI |
What Do Community Logs Show?
1 community protocol logs include TB-500. Browse community logs →
How Is TB-500 Used in Research?
Mechanism of action. Binds G-actin and promotes actin sequestration, supporting cell migration and angiogenesis.
Half-life. Estimated multi-hour half-life in animal models.
Storage. Lyophilized: store at -20°C. Reconstituted: refrigerate 2–8°C.
Reconstitution. Reconstituted with bacteriostatic water for research handling. Math only — not dosing guidance. See the reconstitution calculator — a math tool only, not dosing guidance.
What Does TB-500's Evidence Tier Mean?
TB-500 is rated Tier 3 · Animal Only. Evidence limited to animal models. Evidence tiers are a shorthand for how strong the human data is — Tier 1 reflects human randomized controlled trials, while lower tiers rest on observational, animal, or theoretical evidence. A higher tier means more confidence that observed effects are real and caused by the compound rather than by chance or bias. For how to weigh each tier, see our guide to understanding peptide evidence tiers.
How Do You Evaluate TB-500 Sourcing and Quality?
Because research-chemical TB-500 is unregulated, sourcing quality varies widely between sellers. Before trusting any supplier, check its reputation and enforcement history in the ranked list of trusted peptide sellers, and look for a batch-specific certificate of analysis (COA) showing third-party HPLC or LC-MS purity testing. Purity claims without a named lab, a batch number, and a method are marketing, not data. If you are reconstituting lyophilized material, the reconstitution calculator handles the arithmetic — it is a math tool only and not dosing guidance.
Where to Buy TB-500: Trusted & Verified Sellers
TB-500 is supplied by specialist research-chemical sellers rather than pharmacies, so where you buy it matters as much as what you buy. The sellers below have published moderator-approved third-party lab results for TB-500, ranked by overall reputation score. Always confirm a current batch-specific COA before purchasing.
No seller has published a lab result for TB-500 yet. Browse the ranked directory of trusted peptide sellers and check each one's lab testing and enforcement record before buying.
PeptidesHub does not sell TB-500 or facilitate transactions — this list is for research transparency only.
How Are Adverse Reactions to TB-500 Reported?
Structured adverse-event reports help the whole community spot safety signals early. You can browse approved reports on the adverse events page or submit one yourself. For a serious or life-threatening reaction, seek medical care and report it to FDA MedWatch.
Frequently Asked Questions
TB-500 is not fda approved. It is treated as a research compound in the United States.