Melanotan II — Research Evidence & Community Data
Also known as: MT-2, MT-II, alpha-MSH analog
Research & educational use only. This content is not medical advice. Consult a qualified healthcare professional before using any peptide compound.
What Is Melanotan II?
Melanotan II is a synthetic cyclic analog of alpha-melanocyte-stimulating hormone (alpha-MSH) that non-selectively activates melanocortin receptors, producing skin pigmentation and other effects. It is not approved by the FDA for any use, and regulators have warned about unregulated products sold for tanning. Reported effects and adverse events come largely from case reports and small studies rather than controlled efficacy trials.
Is Melanotan II FDA Approved?
Melanotan II is not fda approved. It is treated as a research compound in the United States with no approved human clinical applications.
What Does the Research Show?
As of 2026, there are 0 human randomized controlled trials with a combined 0 subjects, and 15 animal model studies. Evidence is dominated by case reports and small uncontrolled studies. No approved efficacy program.
Case literature reports nausea, blood-pressure changes, and atypical or changing moles; no controlled efficacy trials support tanning use.
No linked evidence entries yet.
What Do Community Logs Show?
No community logs include Melanotan II yet. Browse community logs →
How Is Melanotan II Used in Research?
Mechanism of action. Non-selective agonism of melanocortin receptors (MC1R and others), stimulating melanogenesis.
Half-life. Short plasma half-life.
Storage. Lyophilized: store frozen, protect from light. Reconstituted: refrigerate 2-8C.
Reconstitution. Reconstituted with bacteriostatic water for research handling. Math only - not dosing guidance. See the reconstitution calculator — a math tool only, not dosing guidance.
What Does Melanotan II's Evidence Tier Mean?
Melanotan II is rated Tier 4 · Theoretical. Mechanistic or theoretical basis only. Evidence tiers are a shorthand for how strong the human data is — Tier 1 reflects human randomized controlled trials, while lower tiers rest on observational, animal, or theoretical evidence. A higher tier means more confidence that observed effects are real and caused by the compound rather than by chance or bias. For how to weigh each tier, see our guide to understanding peptide evidence tiers.
How Do You Evaluate Melanotan II Sourcing and Quality?
Because research-chemical Melanotan II is unregulated, sourcing quality varies widely between sellers. Before trusting any supplier, check its reputation and enforcement history in the ranked list of trusted peptide sellers, and look for a batch-specific certificate of analysis (COA) showing third-party HPLC or LC-MS purity testing. Purity claims without a named lab, a batch number, and a method are marketing, not data. If you are reconstituting lyophilized material, the reconstitution calculator handles the arithmetic — it is a math tool only and not dosing guidance.
Where to Buy Melanotan II: Trusted & Verified Sellers
Melanotan II is supplied by specialist research-chemical sellers rather than pharmacies, so where you buy it matters as much as what you buy. The sellers below have published moderator-approved third-party lab results for Melanotan II, ranked by overall reputation score. Always confirm a current batch-specific COA before purchasing.
No seller has published a lab result for Melanotan II yet. Browse the ranked directory of trusted peptide sellers and check each one's lab testing and enforcement record before buying.
PeptidesHub does not sell Melanotan II or facilitate transactions — this list is for research transparency only.
How Are Adverse Reactions to Melanotan II Reported?
Structured adverse-event reports help the whole community spot safety signals early. You can browse approved reports on the adverse events page or submit one yourself. For a serious or life-threatening reaction, seek medical care and report it to FDA MedWatch.
Frequently Asked Questions
Melanotan II is not fda approved. It is treated as a research compound in the United States.