MK-677 vs CJC-1295
Research & educational use only. This content is not medical advice. Consult a qualified healthcare professional before using any peptide compound.
MK-677 and CJC-1295 are both growth hormone peptides that come up together constantly. This is a side-by-side comparison on the data that actually matters — evidence tier, FDA status, human trials, and how to source each safely — not hype. It is for research and educational purposes only.
MK-677 vs CJC-1295: side-by-side
| MK-677 | CJC-1295 | |
|---|---|---|
| Evidence tier | Tier 2 | Tier 4 |
| FDA status | Investigational | Not FDA Approved |
| Human RCTs | 5 | 0 |
| Subjects enrolled | 600 | 0 |
| Animal studies | 20 | 12 |
| Category | growth hormone | growth hormone |
| Half-life | Long half-life supporting once-daily oral dosing. | Modified GRF 1-29 has a short half-life (minutes); the DAC variant is reported in days. |
| Community logs | 1 | 1 |
Key differences
MK-677 rests on stronger human evidence (Tier 2) than CJC-1295 (Tier 4) — that means more confidence its observed effects are real rather than artefacts of weaker study designs. Neither is FDA approved for human use — both are investigational / not fda approved and treated as research compounds in the US.
MK-677 has 5 human trials on record (600 subjects) versus CJC-1295's 0 (0 subjects). Evidence tiers are a shorthand for how strong that human data is — see our guide to understanding peptide evidence tiers for how to weigh them.
What is MK-677?
MK-677 (ibutamoren) is an orally active, non-peptide growth hormone secretagogue that mimics ghrelin at the GHS-R1a receptor to raise growth hormone and IGF-1. Despite extensive clinical investigation it has never received FDA approval, and recognized effects include increased appetite and reduced insulin sensitivity.… Full MK-677 breakdown →
What is CJC-1295?
CJC-1295 is a synthetic analog of growth hormone-releasing hormone (GHRH 1-29), commonly studied alongside ghrelin-mimetic secretagogues. A DAC (drug affinity complex) variant is designed for an extended half-life. It is not FDA-approved and lacks published human efficacy randomized controlled trials; mechanistic data… Full CJC-1295 breakdown →
Where to buy MK-677 or CJC-1295 safely
Both are sold by research-chemical suppliers, not pharmacies, so the source matters as much as the compound. Before buying either, vet sellers on third-party lab testing and enforcement history in the ranked directory of trusted peptide sellers — or jump straight to vetted sources for MK-677 or CJC-1295. PeptidesHub does not sell either compound.
Frequently asked questions
MK-677 and CJC-1295 are both growth hormone peptides. MK-677 rests on stronger human evidence (Tier 2) than CJC-1295 (Tier 4) — that means more confidence its observed effects are real rather than artefacts of weaker study designs. Neither is FDA approved for human use — both are investigational / not fda approved and treated as research compounds in the US. See each compound's full evidence breakdown for the underlying studies.