Semax — Research Evidence & Community Data
Also known as: Russian nootropic peptide, ACTH(4-10) analog
Research & educational use only. This content is not medical advice. Consult a qualified healthcare professional before using any peptide compound.
What Is Semax?
Semax is a synthetic peptide analog of a fragment of adrenocorticotropic hormone (ACTH 4-10), developed in Russia for cognitive and neuroprotective applications. Human clinical use is reported in Russia for stroke and cognition, but it is not FDA-approved and independent randomized controlled trials are limited. It is used in research contexts to study neuroprotection and BDNF expression.
Is Semax FDA Approved?
Semax is investigational. It is treated as a research compound in the United States with no approved human clinical applications.
What Does the Research Show?
As of 2026, there are 2 human randomized controlled trials with a combined 140 subjects, and 30 animal model studies. Russian clinical use for ischemic stroke and cognitive indications; mechanistic and animal data on BDNF. Limited independent Western RCTs.
No linked evidence entries yet.
What Do Community Logs Show?
1 community protocol logs include Semax. Browse community logs →
How Is Semax Used in Research?
Mechanism of action. Increases BDNF and NGF expression; modulates the dopaminergic and serotonergic systems.
Half-life. Short plasma half-life; intranasal route common.
Storage. Powder stored frozen; solutions refrigerated.
Reconstitution. Commonly intranasal in studies. Reconstitution math only — not medical advice. See the reconstitution calculator — a math tool only, not dosing guidance.
What Does Semax's Evidence Tier Mean?
Semax is rated Tier 2 · Observational. Supported by human observational or clinical reports. Evidence tiers are a shorthand for how strong the human data is — Tier 1 reflects human randomized controlled trials, while lower tiers rest on observational, animal, or theoretical evidence. A higher tier means more confidence that observed effects are real and caused by the compound rather than by chance or bias. For how to weigh each tier, see our guide to understanding peptide evidence tiers.
How Do You Evaluate Semax Sourcing and Quality?
Because research-chemical Semax is unregulated, sourcing quality varies widely between sellers. Before trusting any supplier, check its reputation and enforcement history in the ranked list of trusted peptide sellers, and look for a batch-specific certificate of analysis (COA) showing third-party HPLC or LC-MS purity testing. Purity claims without a named lab, a batch number, and a method are marketing, not data. If you are reconstituting lyophilized material, the reconstitution calculator handles the arithmetic — it is a math tool only and not dosing guidance.
Where to Buy Semax: Trusted & Verified Sellers
Semax is supplied by specialist research-chemical sellers rather than pharmacies, so where you buy it matters as much as what you buy. The sellers below have published moderator-approved third-party lab results for Semax, ranked by overall reputation score. Always confirm a current batch-specific COA before purchasing.
No seller has published a lab result for Semax yet. Browse the ranked directory of trusted peptide sellers and check each one's lab testing and enforcement record before buying.
PeptidesHub does not sell Semax or facilitate transactions — this list is for research transparency only.
How Are Adverse Reactions to Semax Reported?
Structured adverse-event reports help the whole community spot safety signals early. You can browse approved reports on the adverse events page or submit one yourself. For a serious or life-threatening reaction, seek medical care and report it to FDA MedWatch.
Frequently Asked Questions
Semax is investigational. It is treated as a research compound in the United States.